甲钴胺联合鼠神经生长因子促进脊髓型颈椎病术(5)

结果与结论：在术后1，3，6个月及1年时，两组患者的NDI评分均较术前降低(P＜ 0.05)，JOA评分均较术前升高(P＜ 0.05)；治疗6个月和1年时，研究组NDI评分显著低于对照组(P＜ 0.05)，JOA评分显著高于对照组(P＜ 0.05)。结果表明甲钴胺联合鼠神经生长因子有助于脊髓型颈椎病患者术后神经功能的恢复，且效果优于单用鼠神经生长因子治疗。

BACKGROUND:Cervical spondylotic myelopathy is a common degenerative disease of the cervical spine in spinal surgery. Surgical decompression is the most effective method to prevent the further development of the disease. However, patients are often accompanied by residual neurological symptoms such as sensory and motor dysfunction after surgery. Currently, the drug treatment for postoperative neurological recovery of patients is still unclear clinically.

OBJECTIVE:To investigate the effect of mecobalamine combined with mouse nerve growth factor on the recovery of nerve function after cervical spondylotic myelopathy surgery.

METHODS:A total of 82 cases of cervical spondylotic myelopathy from June 2017 to September 2018 in the Affiliated Hospital of Xuzhou Medical University were enrolled in this study. All the patients were randomly divided into observation group and control group with 41 cases in each. Mouse nerve growth factor injection was applied to the control group, and mecobalamine injection was added to the research group. All the patients were treated for 2 symptoms and signs in both groups were respectively recorded before and after the treatment, and postoperative residual neurological symptoms were evaluated by Neck Disability Index (NDI) scores and Japanese Orthopedic Association scores.

RESULTS AND CONCLUSION:At 1 month, 3 months, 6 months and 1 year after the operation, the NDI scores of the two groups were lower than those before the treatment, and the JOA scores were both getting higher than those before the treatment. The NDI scores in the observation group at 6 months and 1 year after the operation were significantly lower than those in the control group, and as well, the Japanese Orthopedic Association scores were significantly higher than those in the control group. These findings indicate that the combination of mecobalamine and mouse nerve growth factor is helpful to the recovery of nerve function in patients after cervical spondylotic myelopathy surgery, and the effect is better than that of mouse nerve growth factor alone.

文章来源：《临床神经外科杂志》 网址: http://www.lcsjwkzzzz.cn/qikandaodu/2021/0414/481.html